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Select item 46743191.

Systemic administration and targeted radiosensitization via chemically synthetic aptamer-siRNA chimeras in human tumor xenografts

Xiaohua Ni, Yonggang Zhang, Kenji Zennami, Mark Castanares, Amarnath Mukherjee, Raju R. Raval, Haoming Zhou, Theodore L. DeWeese, Shawn E. Lupold

Mol Cancer Ther. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Mol Cancer Ther. 2015 Dec; 14(12): 2797–2804. Published online 2015 Oct 5. doi: 10.1158/1535-7163.MCT-15-0291-T

PMCID:: PMC4674319

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Select item 74846752.

NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1

Li-Ching Lin, Hsueh-Te Lee, Peng-Ju Chien, Yu-Hao Huang, Mu-Ya Chang, Yueh-Chun Lee, Wen-Wei Chang

Int J Med Sci. 2020; 17(14): 2214–2224. Published online 2020 Aug 19. doi: 10.7150/ijms.45706

PMCID:: PMC7484675

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AZD5438, an Inhibitor of Cdk1, 2, and 9, Enhances the Radiosensitivity of Non-Small Cell Lung Carcinoma Cells

Pavithra Raghavan, Vasu Tumati, Lan Yu, Norman Chan, Nozomi Tomimatsu, Sandeep Burma, Robert G. Bristow, Debabrata Saha

Int J Radiat Oncol Biol Phys. Author manuscript; available in PMC 2013 Nov 15.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2012 Nov 15; 84(4): e507–e514. Published online 2012 Jul 12. doi: 10.1016/j.ijrobp.2012.05.035

PMCID:: PMC3623267

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Select item 64997654.

Modeling long-term tumor growth and kill after combinations of radiation and radiosensitizing agents

Tim Cardilin, Joachim Almquist, Mats Jirstrand, Astrid Zimmermann, Floriane Lignet, Samer El Bawab, Johan Gabrielsson

Cancer Chemother Pharmacol. 2019; 83(6): 1159–1173. Published online 2019 Apr 11. doi: 10.1007/s00280-019-03829-y

PMCID:: PMC6499765

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Select item 95013845.

Natural Radiosensitizers in Radiotherapy: Cancer Treatment by Combining Ionizing Radiation with Resveratrol

Dominika Komorowska, Tomasz Radzik, Sebastian Kalenik, Aleksandra Rodacka

Int J Mol Sci. 2022 Sep; 23(18): 10627. Published online 2022 Sep 13. doi: 10.3390/ijms231810627

PMCID:: PMC9501384

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Select item 49768226.

Arsenic trioxide as a radiation sensitizer for ¹³¹I-metaiodobenzylguanidine therapy: Results of a phase II study

Shakeel Modak, Pat Zanzonico, Jorge A. Carrasquillo, Brian H. Kushner, Kim Kramer, Nai-Kong V. Cheung, Steven M. Larson, Neeta Pandit-Taskar

J Nucl Med. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: J Nucl Med. 2016 Feb; 57(2): 231–237. Published online 2016 Jan 7. doi: 10.2967/jnumed.115.161752

PMCID:: PMC4976822

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Select item 102992227.

Radiosensitizing Effects of Irinotecan versus Oxaliplatin Alone and in Combination with 5-Fluorouracil on Human Colorectal Cancer Cells

Bernd Frerker, Felix Bock, Marie-Louise Cappel, Stephan Kriesen, Gunther Klautke, Guido Hildebrandt, Katrin Manda

Int J Mol Sci. 2023 Jun; 24(12): 10385. Published online 2023 Jun 20. doi: 10.3390/ijms241210385

PMCID:: PMC10299222

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Characterization of in vitro radiosensitization in mammalian cells using biomathematical modelling: implications for hypofractionated radiotherapy with a combined modality approach

Yuji Seo, Keisuke Tamari, Yasuo Yoshioka, Fumiaki Isohashi, Osamu Suzuki, Kazuhiko Hayashi, Yutaka Takahashi, SungJae Baek, Keisuke Otani, Kazuhiko Ogawa

Br J Radiol. June 2016; 89(1062): 20150724. Published online 2016 Apr 11. doi: 10.1259/bjr.20150724

PMCID:: PMC5258145

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Select item 89407919.

Exposure-response modeling improves selection of radiation and radiosensitizer combinations

Tim Cardilin, Joachim Almquist, Mats Jirstrand, Astrid Zimmermann, Floriane Lignet, Samer El Bawab, Johan Gabrielsson

J Pharmacokinet Pharmacodyn. 2022; 49(2): 167–178. Published online 2021 Oct 8. doi: 10.1007/s10928-021-09784-7

PMCID:: PMC8940791

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Select item 236274110.

Phase I/II study of weekly irinotecan and concurrent radiation therapy for locally advanced non-small cell lung cancer

K Takeda, S Negoro, S Kudoh, K Okishio, N Masuda, M Takada, M Tanaka, T Nakajima, T Tada, M Fukuoka

Br J Cancer. 1999 Mar; 79(9-10): 1462–1467. doi: 10.1038/sj.bjc.6690233

PMCID:: PMC2362741

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Select item 375070711.

Preclinical Evaluation of Genexol-PM, a Nanoparticle Formulation of Paclitaxel, as a Novel Radiosensitizer for the Treatment of Non-Small Cell Lung Cancer

Michael E. Werner, Natalie D. Cummings, Manish Sethi, Edina C. Wang, Rohit Sukumar, Dominic T. Moore, Andrew Z. Wang

Int J Radiat Oncol Biol Phys. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2013 Jul 1; 86(3): 463–468. doi: 10.1016/j.ijrobp.2013.02.009

PMCID:: PMC3750707

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Select item 960716112.

JNC-1043, a Novel Podophyllotoxin Derivative, Exerts Anticancer Drug and Radiosensitizer Effects in Colorectal Cancer Cells

Jin-Hee Kwon, Na-Gyeong Lee, A-Ram Kang, In-Ho Ahn, In-Young Choi, Jie-Young Song, Sang-Gu Hwang, Hong-Duck Um, Jong-Ryoo Choi, Joon Kim, Jong Kuk Park

Molecules. 2022 Oct; 27(20): 7008. Published online 2022 Oct 18. doi: 10.3390/molecules27207008

PMCID:: PMC9607161

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Select item 677124613.

Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage

Yuyang Zhou, Ying Xu, Lunjie Lu, Jingyang Ni, Jihua Nie, Jianping Cao, Yang Jiao, Qi Zhang

Theranostics. 2019; 9(22): 6665–6675. Published online 2019 Sep 18. doi: 10.7150/thno.34015

PMCID:: PMC6771246

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Select item 938732414.

A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma

Shuyue Zhang, Xiuxiu Jiao, Michal Heger, Shen Gao, Mei He, Nan Xu, Jigang Zhang, Mingjian Zhang, Yuan Yu, Baoyue Ding, Xueying Ding

Drug Deliv. 2022; 29(1): 2658–2670. Published online 2022 Aug 16. doi: 10.1080/10717544.2022.2108937

PMCID:: PMC9387324

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Select item 1067051715.

Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control

Martina Ferioli, Anna M. Perrone, Milly Buwenge, Alessandra Arcelli, Maria Vadala’, Bruno Fionda, Maria C. Malato, Pierandrea De Iaco, Claudio Zamagni, Silvia Cammelli, Luca Tagliaferri, Alessio G. Morganti

Curr Oncol. 2023 Nov; 30(11): 9895–9905. Published online 2023 Nov 13. doi: 10.3390/curroncol30110719

PMCID:: PMC10670517

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Select item 735632016.

Uracil-5-yl O-Sulfamate: An Illusive Radiosensitizer. Pitfalls in Modeling the Radiosensitizing Derivatives of Nucleobases

Paulina Spisz, Magdalena Zdrowowicz, Witold Kozak, Lidia Chomicz-Mańka, Karina Falkiewicz, Samanta Makurat, Artur Sikorski, Dariusz Wyrzykowski, Janusz Rak, Eugene Arthur-Baidoo, Patrick Ziegler, Mateus Salomao Rodrigues Costa, Stephan Denifl

J Phys Chem B. 2020 Jul 9; 124(27): 5600–5613. Published online 2020 Jun 15. doi: 10.1021/acs.jpcb.0c03844

PMCID:: PMC7356320

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Select item 591790117.

A New, Potent 2‐Nitroimidazole Nucleoside Hypoxic Cell Radiosensitizer, RP170

Keisuke Sasai, Yuta Shibamoto, Masaji Takahashi, Mitsuyuki Abe, Jun Wang, Lin Zhou, Sei‐ichi Nishimoto, Tsutomu Kagiya

Jpn J Cancer Res. 1989 Nov; 80(11): 1113–1118. doi: 10.1111/j.1349-7006.1989.tb02267.x

PMCID:: PMC5917901

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Select item 747034018.

Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas

Radu O. Minea, Tuan Cao Duc, Stephen D. Swenson, Hee-Yeon Cho, Mickey Huang, Hannah Hartman, Florence M. Hofman, Axel H. Schönthal, Thomas C. Chen

PLoS One. 2020; 15(9): e0238238. Published online 2020 Sep 3. doi: 10.1371/journal.pone.0238238

PMCID:: PMC7470340

Article PDF–7.7M

Select item 578474219.

Model‐Based Evaluation of Radiation and Radiosensitizing Agents in Oncology

Tim Cardilin, Joachim Almquist, Mats Jirstrand, Astrid Zimmermann, Samer El Bawab, Johan Gabrielsson

CPT Pharmacometrics Syst Pharmacol. 2018 Jan; 7(1): 51–58. Published online 2017 Dec 14. doi: 10.1002/psp4.12268

PMCID:: PMC5784742

Article PDF–417K

Select item 361056820.

Identification and Biological Evaluation of a Novel and Potent Small Molecule Radiation Sensitizer via an Unbiased Screen of a Chemical Library

Brian E. Lally, Geoffrey A. Geiger, Steven Kridel, Alice E. Arcury-Quandt, Michael E. Robbins, Nancy D. Kock, Kenneth Wheeler, Prakash Peddi, Alexandros Georgakilas, Gary D. Kao, Constantinos Koumenis

Cancer Res. Author manuscript; available in PMC 2013 Mar 28.

Published in final edited form as: Cancer Res. 2007 Sep 15; 67(18): 8791–8799. doi: 10.1158/0008-5472.CAN-07-0477

PMCID:: PMC3610568

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PMC Images search for radiosensitizer

Figure 4

CNS progression in the trial included in this meta-analysis comparing WBRT with radiosensitizer to WBRT alone.

Whole brain radiotherapy with radiosensitizer for brain metastases

J Exp Clin Cancer Res. 2009;28(1):1-1.
Figure 3

Local brain tumor response in the trials included in this meta-analysis comparing WBRT with radiosensitizer to WBRT alone.

Whole brain radiotherapy with radiosensitizer for brain metastases

J Exp Clin Cancer Res. 2009;28(1):1-1.
Fig. 7

Hypothetical costs Ψ using the NTCP model (Eq. ) for radiation and radiosensitizer combinations, A₁ (green), A₂ (blue), and A₃ (purple), along the TSE curves in Fig. . The left plot assumes equal toxicity, whereas the right plot assumes a tenfold increase for radiosensitizer A₁ (color figure online)

Exposure-response modeling improves selection of radiation and radiosensitizer combinations

J Pharmacokinet Pharmacodyn. 2022;49(2):167-178.
Figure 3

In vivo mechanism of ¹²⁵ I-cRGD-GNPs. (A) SPECT/CT images of tumor-bearing mice at 1, 2, and 4 h post injection; tumor tissues were circled and T/NT values were marked. (B) Changes of %ID/g of metabolins from the kidney and intestine. (C) Concentration change of radiosensitizer in the blood. (D) In vivo retained amount of targeted radiosensitizer reflected by retained radioactivity.

Iodine-125-labeled cRGD-gold nanoparticles as tumor-targeted radiosensitizer and imaging agent

Nanoscale Res Lett. 2015;10:160.